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Product Details:

  • Product Name: Vorinostat
  • CAS #: 149647-78-9
  • Mode of Action:

    Vorinostat inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II) at nanomolar concentrations (IC5_

  • Metabolism:

    The major pathways of vorinostat metabolism involve glucuronidation and hydrolysis followed by _-oxidation. Human serum levels of two metabolites, O-glucuronide of vorinostat and 4-anilino-4-oxobutanoic acid were measured. Both metabolites are pharmacologically inactive. Compared to vorinostat, the mean steady state serum exposures in humans of the O-glucuronide of vorinostat and 4-anilino-4-oxobutanoic acid were 4-fold and 13-fold higher, respectively. In vitro studies using human liver microsomes indicate negligible biotransformation by cytochromes P450 (CYP).

  • IUPAC: N-hydroxy-N'-phenyloctanediamide
  • ATC: L01XX38
  • PubChem: 5311
  • DrugBank: DB02546 (EXPT02902)
  • Formula: C19H16O4
  • Molecular Mass: 264.3202
  • Synonyms: MK0683 N-hydroxy-n'-phenyloctanediamide N-hyrdroxy-n'-phenyloctanediamide SAHA SHH Suberanilohydroxamic acid suberoylanilide hydroxamic acid
  • General Reference:

    1. Munshi A, Tanaka T, Hobbs ML, Tucker SL, Richon VM, Meyn RE: Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci. Mol Cancer Ther. 2006 Aug;5(8):1967-74. Pubmed

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