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Product Details:

  • Product Name: Tolnaftate
  • CAS #: 2398-96-1
  • Mode of Action:

    Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.

  • Pharmacodynamics:

    Tolnaftate is a synthetic over-the-counter anti-fungal agent.

  • Toxicity:

    Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.

  • IUPAC: N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide
  • ATC: D01AE18
  • PubChem: 5510
  • DrugBank: DB00525 (APRD01607)
  • Formula: C22H31NO
  • Molecular Mass: 307.409
  • SMILES: CN(C(=S)OC1=CC2=CC=CC=C2C=C1)C1=CC=CC(C)=C1
  • AHFS Code: 84:04.08.40
  • InChl: FUSNMLFNXJSCDI-UHFFFAOYSA-N
  • General Reference:

    1. Barrett-Bee K, Dixon G: Ergosterol biosynthesis inhibition: a target for antifungal agents. Acta Biochim Pol. 1995;42(4):465-79. Pubmed
    2. Ryder NS, Frank I, Dupont MC: Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother. 1986 May;29(5):858-60. Pubmed

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