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Theophylline

  • # LGM Pharma is a Theophylline CAS# 58-55-9 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
  • # Questions? Call our customer API support number 1-(800)-881-8210.
  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
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Product Details:

  • Product Name: Theophylline
  • CAS #: 58-55-9
  • Mode of Action:

    Theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Theophylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Theophylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction.

  • Pharmacodynamics:

    Theophylline, an xanthine derivative chemically similar to caffeine and theobromine, is used to treat asthma and bronchospasm. Theophylline has two distinct actions in the airways of patients with reversible (asthmatic) obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., non-bronchodilator prophylactic effects).

  • Metabolism:

    Hepatic. Biotransformation takes place through demethylation to 1-methylxanthine and 3-methylxanthine and hydroxylation to 1, 3-dimethyluric acid. 1-methylxanthine is further hydroxylated, by xanthine oxidase, to 1-methyluric acid. About 6% of a theophylline dose is N-methylated to caffeine. Caffeine and 3-methylxanthine are the only theophylline metabolites with pharmacologic activity.

  • Toxicity:

    Symptoms of overdose include seizures, arrhythmias, and GI effects.

  • IUPAC: 1, 3-dimethyl-2, 3, 6, 7-tetrahydro-1H-purine-2, 6-dione
  • ATC: R03DA04 R03DA05
  • PubChem: 2153
  • DrugBank: DB00277 (APRD00082)
  • Formula: C6H12N3PS
  • Molecular Mass: 180.164
  • Synonyms: Dimethylxanthine Pseudotheophylline Theophyline Theophyllin Theophylline aminoacetate Theophylline Anhydrous
  • SMILES: CN1C2=C(NC=N2)C(=O)N(C)C1=O
  • AHFS Code: 26:16.0
  • InChl: ZFXYFBGIUFBOJW-UHFFFAOYSA-N
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