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Simeprevir Sodium

CAS No:
1241946-89-3 Categories: , ,
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Product Details:

  • Product Name: Simeprevir Sodium
  • CAS #: 1241946-89-3
  • Mode of Action:

    Simeprevir functions as a direct-acting antiviral agent because it inhibits hepatitis C viral replication by binding to and inhibiting the protease, hepatitis C virus (HCV) NS3/4A.

  • Pharmacodynamics:

    Simeprevir is a protease inhibitor for HCV NS3/4A protease, which is required for replication of the virus.

  • Metabolism:

    Simeprevir is mainly metabolized by CYP3A enzymes.

  • Toxicity:

    In patients receiving the combination therapy, the most common adverse reactions were nausea, pruritus, photosensitivity, and rash.

  • ATC: J05AE14
  • DrugBank: DB06290
  • General Reference:

    1. Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wahling H, Wickstrom K, Hamelink E, Edlund M, Vrang L, Vendeville S, Van de Vreken W, McGowan D, Tahri A, Hu L, Boutton C, Lenz O, Delouvroy F, Pille G, Surleraux D, Wigerinck P, Samuelsson B, Simmen K: Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8. doi: 10.1016/j.bmcl.2008.07.088. Epub 2008 Jul 24. Pubmed
    2. FDA label.

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