21256-18-8 Category:
  • # LGM Pharma is a Oxaprozin CAS# 21256-18-8 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
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  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
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Product Details:

  • Product Name: Oxaprozin
  • CAS #: 21256-18-8
  • Mode of Action:

    Anti-inflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Oxaprozin is a non-selective NSAID, with a cell assay system showing lower COX-2 selectivity implying higher COX-1 selectivity.

  • Pharmacodynamics:

    Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Oxaprozin is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain.

  • Metabolism:

    Hepatic. Ester and ether glucuronide are the major conjugated metabolites of oxaprozin, and do not have significant pharmacologic activity.

  • Toxicity:

    Oral, mouse: LD50 = 1210 mg/kg; Oral, rabbit: LD50 = 172 mg/kg; Oral, rat: LD50 = 4470 mg/kg

  • IUPAC: 3-(diphenyl-1, 3-oxazol-2-yl)propanoic acid
  • ATC: M01AE12
  • PubChem: 4614
  • DrugBank: DB00991 (APRD00030)
  • Formula: C22H31NO3
  • Molecular Mass: 293.3166
  • Synonyms: Oxaprozina [INN-Spanish] Oxaprozine [INN-French] Oxaprozinum [INN-Latin]
  • AHFS Code: 28:08.04.92
  • General Reference:

    1. Heller B, Tarricone R: Oxaprozin versus diclofenac in NSAID-refractory periarthritis pain of the shoulder. Curr Med Res Opin. 2004 Aug;20(8):1279-90. Pubmed

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