Placeholder

Oxaprozin

CAS No:
21256-18-8 Category:
  • # LGM Pharma is a Oxaprozin CAS# 21256-18-8 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
  • # Questions? Call our customer API support number 1-(800)-881-8210.
  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
  • Inquire about this product >>

Product Details:

  • Product Name: Oxaprozin
  • CAS #: 21256-18-8
  • Mode of Action:

    Anti-inflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Oxaprozin is a non-selective NSAID, with a cell assay system showing lower COX-2 selectivity implying higher COX-1 selectivity.

  • Pharmacodynamics:

    Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Oxaprozin is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain.

  • Metabolism:

    Hepatic. Ester and ether glucuronide are the major conjugated metabolites of oxaprozin, and do not have significant pharmacologic activity.

  • Toxicity:

    Oral, mouse: LD50 = 1210 mg/kg; Oral, rabbit: LD50 = 172 mg/kg; Oral, rat: LD50 = 4470 mg/kg

  • IUPAC: 3-(diphenyl-1, 3-oxazol-2-yl)propanoic acid
  • ATC: M01AE12
  • PubChem: 4614
  • DrugBank: DB00991 (APRD00030)
  • Formula: C22H31NO3
  • Molecular Mass: 293.3166
  • Synonyms: Oxaprozina [INN-Spanish] Oxaprozine [INN-French] Oxaprozinum [INN-Latin]
  • SMILES: OC(=O)CCC1=NC(=C(O1)C1=CC=CC=C1)C1=CC=CC=C1
  • AHFS Code: 28:08.04.92
  • InChl: OFPXSFXSNFPTHF-UHFFFAOYSA-N
  • General Reference:

    1. Heller B, Tarricone R: Oxaprozin versus diclofenac in NSAID-refractory periarthritis pain of the shoulder. Curr Med Res Opin. 2004 Aug;20(8):1279-90. Pubmed

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

API’s From Quality Manufacturers:

  • Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
  • Premium quality GMP certified and fully accredited API manufacturing plants

 

  • Technical packages as well as access to filed DMF,
    ASMF or CEP (subject to availability)
  • Regulatory and technical assistance towards any
    submission type based on specific customer requirements
This website uses cookies. By using our site, you agree to our terms of service