7681-93-8 Categories: , ,
  • # LGM Pharma is a Natamycin CAS# 7681-93-8 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
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  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
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Product Details:

  • Product Name: Natamycin
  • CAS #: 7681-93-8
  • Mode of Action:

    LIke other polyene antibiotics, Natamycin inhibits fungal growth by binding to sterols. Specifically, Natamycin binds to ergosterol in the plasma membrane, preventing ergosterol-dependent fusion of vacuoles, as well as membrane fusion and fission. This differs from the mechanism of most other polyene antibiotics, which tend to work by altering fungal membrane permeability instead.

  • Pharmacodynamics:

    Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.

  • IUPAC: (1R, 3S, 5R, 7R, 8E, 12R, 14E, 16E, 18E, 20E, 22R, 24S, 25R, 26S)-22-{[(3S, 4S, 5S, 6R)-4-amino-3, 5-dihydroxy-6-methyloxan-2-yl]oxy}-1, 3, 26-trihydroxy-12-methyl-10-oxo-6, 11, 28-trioxatricyclo[, {5, 7}]octacosa-8, 14, 16, 18, 20-pentaene-25-carboxylic acid
  • ATC: A01AB10 A07AA03 D01AA02 G01AA02 S01AA10
  • PubChem: 441382
  • DrugBank: DB00826 (APRD01136)
  • Formula: C19H17NO7
  • Molecular Mass: 665.7252
  • SMILES: C[C@H]1OC(O[C@@H]2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(O)=O)C[C@@H](O)C[C@H]3O[C@@H]3C=CC(=O)O[C@H](C)CC=CC=CC=CC=C2)[C@@H](O)[C@@H](N)[C@@H]1O
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