Placeholder

Natamycin

CAS No:
7681-93-8 Categories: , ,
  • # LGM Pharma is a Natamycin CAS# 7681-93-8 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
  • # Questions? Call our customer API support number 1-(800)-881-8210.
  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
  • Inquire about this product >>

Product Details:

  • Product Name: Natamycin
  • CAS #: 7681-93-8
  • Mode of Action:

    LIke other polyene antibiotics, Natamycin inhibits fungal growth by binding to sterols. Specifically, Natamycin binds to ergosterol in the plasma membrane, preventing ergosterol-dependent fusion of vacuoles, as well as membrane fusion and fission. This differs from the mechanism of most other polyene antibiotics, which tend to work by altering fungal membrane permeability instead.

  • Pharmacodynamics:

    Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.

  • IUPAC: (1R, 3S, 5R, 7R, 8E, 12R, 14E, 16E, 18E, 20E, 22R, 24S, 25R, 26S)-22-{[(3S, 4S, 5S, 6R)-4-amino-3, 5-dihydroxy-6-methyloxan-2-yl]oxy}-1, 3, 26-trihydroxy-12-methyl-10-oxo-6, 11, 28-trioxatricyclo[22.3.1.0, {5, 7}]octacosa-8, 14, 16, 18, 20-pentaene-25-carboxylic acid
  • ATC: A01AB10 A07AA03 D01AA02 G01AA02 S01AA10
  • PubChem: 441382
  • DrugBank: DB00826 (APRD01136)
  • Formula: C19H17NO7
  • Molecular Mass: 665.7252
  • SMILES: C[C@H]1OC(O[C@@H]2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(O)=O)C[C@@H](O)C[C@H]3O[C@@H]3C=CC(=O)O[C@H](C)CC=CC=CC=CC=C2)[C@@H](O)[C@@H](N)[C@@H]1O
  • InChl: NCXMLFZGDNKEPB-BQGNJOPGSA-N
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

API’s From Quality Manufacturers:

  • Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
  • Premium quality GMP certified and fully accredited API manufacturing plants

 

  • Technical packages as well as access to filed DMF,
    ASMF or CEP (subject to availability)
  • Regulatory and technical assistance towards any
    submission type based on specific customer requirements
This website uses cookies. By using our site, you agree to our terms of service