24219-97-4 Category:
  • # LGM Pharma is a Mianserin CAS# 24219-97-4 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
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  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
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Product Details:

  • Product Name: Mianserin
  • CAS #: 24219-97-4
  • Mode of Action:

    Mianserin's mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.

  • Pharmacodynamics:

    Mianserin is a tetracyclic antidepressant that has antihistaminic and hypnosedative, but almost no anticholinergic, effect. It is a weak inhibitor of norepinephrine reuptake and strongly stimulates the release of norepinephrine. Interactions with serotonin receptors in the central nervous system have also been found. Its effect is usually noticeable after one to three weeks. Mianserin may cause drowsiness and hematological problems.

  • Metabolism:


  • Toxicity:

    Oral rat LD50: 780mg/kg

  • IUPAC: 5-methyl-2, 5-diazatetracyclo[, {2, 7}.0, {8, 13}]nonadeca-1(15), 8(13), 9, 11, 16, 18-hexaene
  • ATC: N06AX03
  • PubChem: 4184
  • DrugBank: DB06148
  • Formula: C8H17NO5
  • Molecular Mass: 264.3648
  • Synonyms: Mianserina [inn-spanish] Mianserine Mianserine [inn-french] Mianserinum [inn-latin] Mianseryna [polish]
  • General Reference:

    1. Koyama E, Chiba K, Tani M, Ishizaki T: Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers. J Pharmacol Exp Ther. 1996 Jul;278(1):21-30. Pubmed
    2. de Boer TH, Nefkens F, van Helvoirt A, van Delft AM: Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazapine, mianserin and idazoxan. J Pharmacol Exp Ther. 1996 May;277(2):852-60. Pubmed
    3. Kelder J, Funke C, De Boer T, Delbressine L, Leysen D, Nickolson V: A comparison of the physicochemical and biological properties of mirtazapine and mianserin. J Pharm Pharmacol. 1997 Apr;49(4):403-11. Pubmed

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