• # LGM Pharma is a Glucarpidase CAS# 9074-87-7 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
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  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
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Product Details:

  • Product Name: Glucarpidase
  • CAS #: 9074-87-7
  • Mode of Action:

    Glucarpidase inactivates methotrexate, and other antifolates, by hydrolyzing glutamate on the carboxyl terminal of these compounds. For methotrexate specifically, it is hydrolyzed to the inactive metabolites glutamate and 4-deoxy-4-amino-N10-methylpteroic acid (DAMPA).

  • Pharmacodynamics:

    Glucarpidase acts as an antidote to toxic methotrexate levels by elminating methotrexate by a non-kidney route.

  • Metabolism:

    Metabolism was not determined.

  • Toxicity:

    Most common adverse reactions include hypotension, flushing, nausea, vomiting, headache, and paresthesia.

  • ATC: V03AF09
  • DrugBank: DB08898
  • Formula: C1950H3157N543O599S7
  • Molecular Mass: 44016.6653 g/mol
  • Synonyms: Carboxypeptidase G2
  • General Reference:

    1. Green JM: Glucarpidase to combat toxic levels of methotrexate in patients. Ther Clin Risk Manag. 2012;8:403-13. doi: 10.2147/TCRM.S30135. Epub 2012 Nov 22. Pubmed
    2. Tuffaha HW, Al Omar S: Glucarpidase for the treatment of life-threatening methotrexate overdose. Drugs Today (Barc). 2012 Nov;48(11):705-11. doi: 10.1358/dot.2012.48.11.1871575. Pubmed
    3. FDA label.

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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