58-32-2 Categories: , ,
  • # LGM Pharma is a Dipyridamole CAS# 58-32-2 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
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  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
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Product Details:

  • Product Name: Dipyridamole
  • CAS #: 58-32-2
  • Mode of Action:

    Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation.

  • Pharmacodynamics:

    Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Dipyridamole is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis.

  • Metabolism:


  • Toxicity:

    Hypotension, if it occurs, is likely to be of short duration, but a vasopressor drug may be used if necessary. The oral LD50 in rats is greater than 6, 000 mg/kg while in the dogs, the oral LD50 is approximately 400 mg/kg. LD50=8.4g/kg (orally in rat)

  • IUPAC: 2-({6-[bis(2-hydroxyethyl)amino]-4, 8-bis(piperidin-1-yl)pyrimido[5, 4-d][1, 3]diazin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol
  • ATC: B01AC07 C01DX20
  • DrugBank: DB00975 (APRD00360)
  • Formula: C17H26N4O
  • Molecular Mass: 504.6256
  • Synonyms: Dipiridamol Dipyridamine Dipyridamol Dipyudamine Dypyridamol Usaf Ge-12
  • AHFS Code: 24:12.9
  • General Reference:

    1. Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A: European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci. 1996 Nov;143(1-2):1-13. Pubmed

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