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Cefoxitin

CAS No:
35607-66-0 Categories: , ,
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Product Details:

  • Product Name: Cefoxitin
  • CAS #: 35607-66-0
  • Mode of Action:

    The bactericidal action of cefoxitin results from inhibition of cell wall synthesis.

  • Pharmacodynamics:

    Cefoxitin is a cephamycin antibiotic often grouped with the second-generation cephalosporins. It is active against a broad range of gram-negative bacteria including anaerobes. The methoxy group in the 7a position provides cefoxitin with a high degree of stability in the presence of beta-lactamases, both penicillinases and cephalosporinases, of gram-negative bacteria.

  • Metabolism:

    Minimal (approximately 85 percent of cefoxitin is excreted unchanged by the kidneys over a 6-hour period).

  • Toxicity:

    The acute intravenous LD50 in the adult female mouse and rabbit was about 8.0 g/kg and greater than 1.0 g/kg, respectively. The acute intraperitoneal LD50 in the adult rat was greater than 10.0 g/kg.

  • IUPAC: (6R, 7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • ATC: J01DC01
  • PubChem: 441199
  • DrugBank: DB01331 (EXPT00897)
  • Formula: C21H30N4O4
  • Molecular Mass: 427.452
  • SMILES: CO[C@]1(NC(=O)CC2=CC=CS2)[C@H]2SCC(COC(N)=O)=C(N2C1=O)C(O)=O
  • AHFS Code: 08:12.07.12
  • InChl: WZOZEZRFJCJXNZ-ZBFHGGJFSA-N
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