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Carbamazepine

CAS No:
298-46-4 Category:
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Product Details:

  • Product Name: Carbamazepine
  • CAS #: 298-46-4
  • Mode of Action:

    Carbamazepine inhibits sustained repetitive firing by blocking use-dependent sodium channels. Pain relief is believed to be associated with blockade of synaptic transmission in the trigeminal nucleus and seizure control with reduction of post-tetanic potentiation of synaptic transmission in the spinal cord. Carbamazepine also possesses anticholinergic, central antidiuretic, antiarrhythmic, muscle relaxant, antidepressant (possibly through blockade of norepinephrine release), sedative, and neuromuscular-blocking properties.

  • Pharmacodynamics:

    Carbamazepine, an anticonvulsant structurally similar to tricyclic antidepressants, is used to treat partial seizures, tonic-clonic seizures, pain of neurologic origin such as trigeminal neuralgia, and psychiatric disorders including manic-depressive illness and aggression due to dementia.

  • Metabolism:

    Hepatic

  • Toxicity:

    Mild ingestions cause vomiting, drowsiness, ataxia, slurred speech, nystagmus, dystonic reactions, and hallucinations. Severe intoxications may produce coma, seizures, respiratory depression, and hypotension

  • IUPAC: 2-azatricyclo[9.4.0.0, {3, 8}]pentadeca-1(11), 3(8), 4, 6, 9, 12, 14-heptaene-2-carboxamide
  • ATC: N03AF01
  • PubChem: 2554
  • DrugBank: DB00564 (APRD00337)
  • Formula: C70H92ClN17O14
  • Molecular Mass: 236.2686
  • Synonyms: Carbamezepine
  • SMILES: NC(=O)N1C2=CC=CC=C2C=CC2=CC=CC=C12
  • AHFS Code: 28:12.9
  • InChl: FFGPTBGBLSHEPO-UHFFFAOYSA-N
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