59803-98-4 Categories: , ,
  • # LGM Pharma is a Brimonidine CAS# 59803-98-4 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
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  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
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Product Details:

  • Product Name: Brimonidine
  • CAS #: 59803-98-4
  • Mode of Action:

    Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2). It has a peak ocular hypotensive effect occurring at two hours post-dosing. Fluorophotometric studies in animals and humans suggest that Brimonidine has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow.

  • Pharmacodynamics:

    Brimonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters. It lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow.

  • Metabolism:

    Metabolized primarily by the liver.

  • Toxicity:

    Oral LD50 is 50 mg/kg in mice and 100 mg/kg in rats.

  • IUPAC: 5-bromo-N-(4, 5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine
  • ATC: S01EA05
  • PubChem: 2435
  • DrugBank: DB00484 (APRD00034)
  • Formula: C9H15NO3S
  • Molecular Mass: 292.135
  • Synonyms: Brimonidine tartrate Bromoxidine
  • AHFS Code: 53:32.0
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