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Product Details:

  • Product Name: Amlodipine Besylate
  • CAS #: 111470-99-6
  • Mode of Action:

    L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50 = 25 μM).

  • IUPAC: 2-[(2-Aminoethoxy)methyl]-4-(2-chlo rophenyl)-1, 4-dihydro-6-methyl-3, 5-pyridinedicarbo xylic acid 3-ethyl 5-methyl ester benzenesulfonate
  • ATC: C08CA01
  • PubChem: 60496
  • DrugBank: APRD00520
  • Formula: C20H25ClN2O5.C6H6O3S
  • Molecular Mass: 567.05
  • Synonyms: 2-[(2-AMINOETHOXY)-METHYL]-4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5-PYRIDINEDICARBOXYLIC ACID 3-ETHYL 5-METHYL ESTER BENZENE SULFONATE, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine benzenesulfonate, AMLODIPINE BENZENESULFONATE, AMLODIPINE BESILATE, AMLODIPINE BESYLATE, NORVASC, 3,5-pyridinedicarboxylicacid,2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1, 4-dihydro-6-methyl-,3-ethyl-5-methylester,monobenzenesulfonate, AMLODIPINE BESILATE MM(CRM STANDARD), AMLODIPINE BESYLATE EPY(CRM STANDARD), 2-[(2-aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate, AMLODIPINEBESYLATE(SUBJECTTOPATENTFREE), (+-)-3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate monobenzenesulfonate, 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, monobenzenesulfonate, Amcard, Amdepin, Amdipin, Amlodin, Amlopin, Amlor
  • General Reference:
    1. Arrowsmith, J.E., et al. 1986. J. Med. Chem. 29: 1696-1702. PMID: 2943898
    2. Burges, R.A., et al. 1987. J. Cardiovasc. Pharmacol. 9: 110-119. PMID: 2434785
    3. Packer, M., et al. 1996. N. Engl. J. Med. 335: 1107-1114. PMID: 8813041
    4. Yoshida, J., et al. 2003. Eur. J. Pharmacol. 472: 23-31. PMID: 12860469
    5. Toba, H., et al. 2005 Hypertens. Res. 28: 689-700. PMID: 16392774
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