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Docetaxel


Known as the prostate cancer powerhouse treatment Zytiga, Abiraterone Acetate has recently become a sales powerhouse for Medivation. The reason for the hype centers on a new indication for this potent anti-cancer drug, specifically as an efficacious pre-chemo treatment. Initial FDA approval for Abiraterone was for post-chemotherapy only. As a post-chemo treatment Zytiga was by[…]

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The FDA made a historic move on September 12, 2013 with their nod to approve Pertuzumab, a monoclonal antibody (mAb), as a pre-surgical treatment for patients with early-stage metastatic breast cancer. Pertuzumab is currently approved as a treatment for women with late-stage breast cancer, but it is administered after surgery has been completed. This new[…]

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Patients with late-stage prostate cancer stand to benefit greatly since the approval of Enzalutamide, CAS number 915087-33-1. Sales of the brand name of Enzalutamide, Xtandi, have recently proven to garnish sizable profits for Medivation, the biopharmaceutical parent of this wonder drug. The launch of Enzalutamide in Europe and Asia in upcoming months are projected to[…]

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As an antineoplastic drug used to treat cancer, docetaxel is also known by it’s brand name Taxotere. Docetaxel, CAS numbers 114977-28-5 and 148408-66-6, is primarily used to treat ovarian, breast, and non-small cell lung cancer. Also classified as a plant alkaloid medication, docetaxel is related to Taxol, which is a rare Pacific yew tree Taxus[…]

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Elacridar, an ABCB1 modulator acting as a drug transporter, has been proven to have beneficial effects on the resistance of cancer cells to standard chemotherapeutic agents. This unique delivery system makes resistant cancers more susceptible to standard chemotherapeutic regimen. A study done by Ho Lun Wong et al showed beneficial results when Elacridar was used[…]

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A recent study conducted by the Queens University Belfasts School of Pharmacy revealed the ability of the recombinant protein FKBPL to inhibit tumor growth by disrupting the blood supply to these tumors. This method of cancer treatment called neovascularization is certainly not new with several agents exhibiting the same mode of action already available in[…]

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