Lomustine 13010-47-4

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Lomustine

Lomustine' (or "CCNU")(Marketed under the name CeeNU in US) is an alkylating nitrosourea compound used in chemotherapy. It is in the same family as streptozotocin. This is a highly lipid soluble drug, and thus crosses the blood brain barrier. This property makes it ideal for treating brain tumors, and is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).

Dose

Adults: 100-150mg/m2 PO every 6 weeks (subsequent dose based on WBC)

Dosage Form

10mg, 40mg, 100mg Capsules

Other

It is the "C" in the "PCV" chemotherapy regimen.

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Systematic (IUPAC) name: N-(2-chloroethyl)-N-cyclohexyl-N-nitrosourea
Lomustine CAS number: 13010-47-4
ATC code: L01AD02
PubChem: 3950
DrugBank: APRD00292
Formula: C9H16N3O2
Molecular mass: 233.695 g/mol
Lomustine Assay/Purity: Typically NLT 98%
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