Fomivirsen 160369-77-7
144245-52-3

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Fomivirsen

Fomivirsen (brand name Vitravene) is an antiviral drug. It is used in the treatment of cytomegalovirus retinitis (CMV) in immunocompromised patients, including those with AIDS. It is synthetic 21 member oligonucleotide with phosphorothioate linkages (which are resistant to degradation by nucleases) and has the sequence:

  • 5'-GCG TTT GCT CTT CTT CTT GCG-3'

Mechanism

It is an oligonucleotide that blocks translation of viral mRNA by binding to a coding segment of a key CMV gene. It was the first antisense antiviral approved by the FDA.

Administration

It is available as an intraocular injection in a concentration of 6. 6 mg/mL.

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Systematic (IUPAC) name:
Fomivirsen CAS number: 160369-77-7
144245-52-3
ATC code: S01AD08
PubChem:
DrugBank:
Formula: C204H263N63O114
Molecular mass: 6682.4 g/mol
Fomivirsen Assay/Purity: Typically NLT 98%
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