Amsacrine 51264-14-3
Amsacrine is an antineoplastic agent. It has been used in acute lymphoblastic leukemia.
Mechanism
Its planar fused ring system can intercalate into the DNA of tumor cells, thereby altering the major and minor groove proportions. These alterations to DNA structure inhibit both DNA replication and transcription by reducing association between the affected DNA and: DNA polymerase, RNA polymerase and transcription factors. Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II (compares with the better known agent etoposide).
| Systematic (IUPAC) name: | N-(4-(acridin-9-ylamino)-3-methoxyphenyl)methanesulfonamide |
|---|---|
| Amsacrine CAS number: | 51264-14-3 |
| ATC code: | L01XX01 |
| PubChem: | 2179 |
| DrugBank: | APRD00064 |
| Formula: | C21H19N3O3 |
| Molecular mass: | 393.46 g/mol |
| Amsacrine Assay/Purity: | Typically NLT 98% |
