Urokinase 9039-53-6
Urokinase (Abbokinase), also called urokinase-type Plasminogen Activator (uPA), is a serine protease (EC 3.4.21.73). Urokinase was originally isolated from human urine, but is present in several physiological locations, such as blood stream and the extracellular matrix. The primary physiological substrate is plasminogen, which is an inactive zymogen form of the serine protease plasmin. Activation of plasmin triggers a proteolysis cascade which, depending on the physiological environment participate in thrombolysis or extracellular matrix degradation. This links urokinase to vascular diseases and cancer.
read more [+]| Systematic (IUPAC) name: | Humanurokinase |
|---|---|
| Urokinase CAS number: | 9039-53-6 |
| ATC code: | B01AD04 |
| PubChem: | BTD00030 |
| DrugBank: | BTD00030 |
| Formula: | C1376H2145N383O406S18 |
| Molecular mass: | 31126.5 g/mol |
| Urokinase Assay/Purity: | Typically NLT 98% |
