Meclizine 569-65-3
Meclizine (proposed INN is meclozine) is an antihistamine considered to be an antiemetic. It is sold under the brand names of Bonine, Bonamine, Antivert, Postafen, and Dramamine (Less Drowsy Formulation), and is most commonly used to inhibit nausea and vomiting. Emesafene is a combination of meclizine (1/3) and pyridoxine (2/3). An alternative to dimenhydrinate (Dramamine, Gravol, Gravamin, and Vertirosan), meclizine is considered to be equally effective, but with reduced side effects. Note that in Canada, Antivert (no longer available) was a combination of meclizine and nicotinic acid.
| Systematic (IUPAC) name: |
1-[(4-chlorophenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazine |
| Meclizine CAS number: |
569-65-3 |
| ATC code: |
A04AB04 R06AE05 |
| PubChem: |
4034 |
| DrugBank: |
APRD00354 |
| Formula: |
C25H27ClN2 |
| Molecular mass: |
390.948 g/mol |
| Meclizine Assay/Purity: |
Typically NLT 98% |
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