Ketazolam 27223-35-4

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Ketazolam

Ketazolam (marketed under the brand names Anseren, Ansieten, Ansietil, Marcen, Sedatival, Sedotime, Solatran and Unakalm) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.

Therapeutic uses

It is used for the treatment of anxiety and has similar effectiveness compared to diazepam. Ketazolam also appears to produce a reduced level of side effects such as sedation compared with diazepam and the side effects when they occur tend to be milder. Ketazolam is also an effective antispasmodic drug and is used for the treatment of spasticity.

Availability

Ketazolam is not approved for sale in Australia, Canada, United Kingdom or the United States. In South Africa, GlaxoSmithKline markets ketazolam under its Solatran brand name.

Tolerance and physical dependence

Chronic use of ketazolam as with other benzodiazepines can lead to physical dependence and the appearance of the benzodiazepine withdrawal syndrome upon cessation of use or decrease in dose. Tolerance to ketazolam's therapeutic effects occurs over a period of 15 days.

Contraindications and special caution

Benzodiazepines require special precaution if used in the elderly, during pregnancy, in children, alcohol or drug-dependent individuals and individuals with comorbid psychiatric disorders.

Pharmacokinetics

Ketazolam breaks down in the blood to diazepam which breaks down to demoxepam which breaks down to desmethyldiazepam.

Warnings

The U. S. Food and Drug Administration warns that in Spain, ketazolam marketed as Marcen may sometimes be mistakenly confused with Narcan.

Legal status

Ketazolam is a List II drugs of the Opium Law in the Netherlands. Ketazolam is a Schedule IV drug under the drugs misuse act in the US.

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Systematic (IUPAC) name: 11-chloro- 8,12b-dihydro- 2,8-dimethyl- 12b-phenyl- 4H-[1,3]oxazino[3,2-d] [1,4]benzodiazepine- 4,7(6H)- dione
Ketazolam CAS number: 27223-35-4
ATC code: N05BA10
PubChem: 33746
DrugBank:
Formula: C20H17N2O3
Molecular mass: 368.8 g/mol
Ketazolam Assay/Purity: Typically NLT 98%
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