Ifosfamide 3778-73-2

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Ifosfamide

Ifosfamide (pronounced eye. fos'. fa. mide) (also marketed as Mitoxana and Ifex) is a nitrogen mustard alkylating agent used in the treatment of cancer. It is sometimes abbreviated "IFO".

Uses

It is given as a treatment for a variety of cancers, including:

  • Testicular cancer
  • Breast cancer
  • Lymphoma (Hodgkin's and Non-Hodgkin's)
  • Soft tissue sarcoma
  • Osteogenic sarcoma
  • Lung cancer
  • Cervical cancer
  • Ovarian cancer
  • Bone cancer

Administration

It is a white powder which, when prepared for use in chemotherapy becomes a clear, colorless fluid. The delivery is intravenous. Ifosfamide is often used in conjunction with Mesna to avoid internal bleeding in the patient, in particular hemorrhagic cystitis.

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Systematic (IUPAC) name: N-3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amide-2-oxide
Ifosfamide CAS number: 3778-73-2
ATC code: L01 AA06
PubChem: 3690
DrugBank: APRD00007
Formula: C7H15N2O2
Molecular mass: 261.1 g/mol
Ifosfamide Assay/Purity: Typically NLT 98%
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