Fenoldopam 67227-57-0

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Fenoldopam

Fenoldopam (Corlopam) is a drug and synthetic benzazepine derivative which acts as a peripheral selective D1 receptor weak partial agonist/antagonist and is used as an antihypertensive.

Indications

Fenoldopam is used as an antihypertensive agent postoperatively, and also via IV to treat hypertensive crisis.

Pharmacology

By activating peripheral D1 receptors, fenoldopam causes arterial/arteriolar vasodilation leading to a decrease in blood pressure. It is particularly effective in dilating the renal, mesenteric, and coronary arteries, where D1. receptors are found. It decreases afterload and also through specific dopamine receptors along the nephron promoting sodium excretion.

Side effects

Adverse effects include headache, flushing, angina, hypotension, reflex tachycardia, and increased intraocular pressure.

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Systematic (IUPAC) name: (RS)-6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
Fenoldopam CAS number: 67227-57-0
ATC code: C01CA19
PubChem: 3341
DrugBank: APRD00969
Formula:
Molecular mass: 305.76 g/mol
Fenoldopam Assay/Purity: Typically NLT 98%
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