Abafungin 129639-79-8
Abafungin is a broad-spectrum antifungal agent with a novel mechanism of action for the treatment of dermatomycoses. Abasol is a topical cream formulation of abafungin by York Pharma.
Mechanism of action
Like imidazole- and triazole-class antifungals, abafungin inhibits the fungal cytochrome P450 enzyme 14α-demethylase. This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. In addition, abafungin inhibits the enzyme sterol 24-C-methyltransferase, modifying the composition of the fungal membrane. Abafungin has antibiotic activity against gram-positive bacteria as well as sporicidal activity.
| Systematic (IUPAC) name: | N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine |
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| Abafungin CAS number: | 129639-79-8 |
| ATC code: | |
| PubChem: | 159326 |
| DrugBank: | |
| Formula: | C21H22N4O1 |
| Molecular mass: | 378.491 g/mol |
| Abafungin Assay/Purity: | Typically NLT 98% |
