Alclometasone Dipropionate 66734-13-2

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Alclometasone Dipropionate

Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent. Alclometasone Dipropionate marketed as medication Aclovate by GlaxoSmithKline.

Pharmacology

Alclometasone inhibits phospholipase A2 by inducing production of lipocortins; inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).

Indications

Alclometasone cream and onintment are indicated forthe relief of corticosteroid-responsive dermatoses, including:

  • atopic dermatitis
  • eczema
  • psoriasis
  • allergic dermatitis
  • contact dermatitis
  • actinic dermatitis
  • kiss-type allergy
  • skin itch

Alclometasone may be used on sensitive skin sites (face, skinfolds); in pediatric patients 1 year orolder and in geriatric patients.

Contraindications

  • hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
  • cutaneous tuberculosis
  • chicken pox
  • perioral dermatitis
  • acne
  • rosacea
  • open wounds
  • trophic ulcers
  • viral infection of skin
  • skin manifestations of syphilis

    • Side effects

    Alclometasone Adverse reactions/Side effects (sometimes, less than 1-2% cases) include:

    • burning
    • itching
    • erythema
    • skin reddening
    • xerodermia
    • skin irritation
    • acne
    • hypopigmentation
    • prickly heat
    • folliculitis
    • white atrophy
    • hypertrichosis
    • reinfection of skin

    How supplied

    Alclometasone as Aclovate is supplied in:

    • Cream; Topical; 0. 05%
    • Ointment; Topical; 0. 05%
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    Systematic (IUPAC) name: [7-chloro-11-hydroxy- 10,13,16-trimethyl-3-oxo-17- (2-propanoyloxyacetyl)- 7,8,9,11,12, 14,15,16- octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate
    Alclometasone Dipropionate CAS number: 66734-13-2
    ATC code: D07AB10
    PubChem: 5311000
    DrugBank: APRD00783
    Formula: C28H37ClO7
    Molecular mass: 521.05 g/mol
    Alclometasone Dipropionate Assay/Purity: Typically NLT 98%
    Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.