LGM Pharma is a Ketoconazole 65277-42-1 active pharmaceutical ingredient supplier, based in the USA.
Questions? Call our customer API support number 1-(800)-881-8210.
LGM Pharma offers this active ingredient but not the finished dosage forms.Inquire about Ketoconazole
|AHFS Codes:||08:14.08 84:04.08.08|
|ATC code:||D01AC08 G01AF11 J02AB02|
|Molecular Weight:||531.431 g/mol|
|Assay/Purity:||Typically NLT 98%|
Additional Details: [+]
|Indication:||For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.|
|Pharmacodynamics:||Ketoconazole, like clotrimazole, fluconazole, itraconazole, and miconazole, is an imidazole antifungal agent.|
|Mode of Action:||Ketoconazole interacts with 14-_ demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergosterol synthesis and increased fungal cellular permeability. Other mechanisms may involve the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone.|
|Toxicity:||Hepatotoxicity, LD50=86 mg/kg (orally in rat)|
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Any patent infringement and resulting liability is solely at buyer risk.