LGM Pharma is a Gabapentin Enacarbil 478296-72-9 active pharmaceutical ingredient supplier distributor, based in the USA.
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LGM Pharma offers this active ingredient but not the finished dosage forms.Inquire about Gabapentin Enacarbil
|Synonyms:||ASP 8825, ASP8825, Gabapentin enacarbil, GSK 1838262, GSK1838262, Horizant, Regnite, Solzira, UNII-75OCL1SPBQ, XP 13512, XP-13512, XP13512|
|Molecular Weight:||329.3903 g/mol|
|Assay/Purity:||Typically NLT 98%|
|IUPAC Name:||1-(((alpha-isobutanoyloxyethoxy)carbonyl)aminomethyl)-1-cyclohexaneacetic acid|
Additional Details: [+]
For the treatment of adult Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
Since gabapentin enacarbil is a prodrug of gabapentin, it's physiological effects are the same as gabapentin. Concerning PHN, gabapentin prevents allodynia and hyperalgesia.
|Mode of Action:||
Although the exact mechanism of action of gabapentin in RLS and PHN is unknown, it is presumed to involve the descending noradrenergic system, resulting in the activation of spinal alpha2-adrenergic receptors.
Gabapentin enacarbil does not interact with any of the major cytochrome P450 enzymes.
Most common adverse reactions are headache, dizziness, and somnolence.
Cundy KC, Annamalai T, Bu L, De Vera J, Estrela J, Luo W, Shirsat P, Torneros A, Yao F, Zou J, Barrett RW, Gallop MA: XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys. J Pharmacol Exp Ther. 2004 Oct;311(1):324-33. Epub 2004 May 14. [PubMed:15146029 ]
Gabapentin Enacarbil News:
- Gabapentin Enacarbil, CAS# 478296-72-9, is also known as Horizant, which is marketed by GlaxoSmithKline.
- Gabapentin enacarbil is the first medication in its class to be approved for the treatment of moderate-to-severe primary Restless Legs Syndrome.
- The once daily dose of gabapentin enacarbil is typically taken at 5pm.
- Symptoms of RLS tend to occur during periods of rest or inactivity, such as nighttime. There is currently no cure for this chronic condition.
- Restless legs syndrome may also known as Willis-Ekbom disease, or WED.
- RLS adversely affects 2-3 percent of the U.S. population.
- One clinical trial of patients who received gabapentin enacarbil indicated that 67.6 percent of these patients reported a 30 percent reduction in pain associated with their RLS symptoms after being dosed with this drug.
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